刘甜甜，副研究员，医学博士。

教育经历

2009年6月毕业于山东大学医学院，获得学士学位；2014年6月毕业于瑞典卡罗林斯卡医学院，获得博士学位。2014年11月进入山东大学医学院博士后流动站进行相关研究。

科研与学术工作经历

1.2014/11-至今，山东大学，病理学教研室，讲师，助理研究员

2.2014/11-至今，山东大学，医学院流动站，博士后

主持或参加科研项目（课题）

科研项目

1. 国家自然科学基金青年基金，81502409，端粒酶逆转录酶(ＴＥＲＴ) 和β-Catenin异常变化及其相互作用对肝癌发生/肝癌干细胞特性的影响，2016/01-2018/12，22.7万元，在研，主持

2. 国家自然科学基金面上项目, 81571960，RNA结合蛋白LIN28A介导幽门螺杆菌感染恶性转化的调控机制，2016/01-2019/12，70万元，在研，参加

3. 国家自然科学基金面上项目，81572594，基因异质性在乳腺癌转移和化疗中的作用， 2016/01-2019/12，65万，在研，参加

4. 国家自然科学基金青年基金，81000868，Reptin调节端粒酶活性介导胃癌发生的分子机制，2011/01-2013/12，20万，已结题，参加

人才计划项目情况

2016年入选山东大学"青年学者未来计划 "     2016-2021年

代表性研究成果和学术奖励情况

1. 第一作者论文

1. Liu Tiantian#; Wang Na#; Cao Jia; Sofiadis Anastasios; Dinets, Andrii; Zedenius, Jan; Larsson, Catharina; Xu, Dawei, The age- and shorter telomere-dependent TERT promoter mutation in follicular thyroid cell-derived carcinomas., Oncogene, 2013. 33(42), pp 4978-4984

2. Liu, Tiantian; Liang, Xiuming; Li, Bingnan; Bjorkholm, Magnus; Jia, Jihui; Xu, Dawei, Telomerase reverse transcriptase inhibition stimulates cyclooxygenase 2 expression in cancer cells and synergizes with celecoxib to exert anti-cancer effects., British Journal of Cancer, 2013 108(11), pp 2272-2280

3. Na Wang#, Tiantian Liu#, Anastasios Sofiadis, C. Christofer Juhlin, Jan Zedenius, Anders Höög, Catharina Larsson, Dawei Xu, The TERT promoter mutation as an early genetic event in follicular thyroid carcinogenesis. 2014 Cancer, 120(19), pp 2965-2979

4. Xie, Hong#; Liu, Tiantian#; Wang, Na; Bjornhagen, Viveca; Hoog, Anders; Larsson, Catharina; Lui, Weng-Onn; Xu, Dawei, TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma., Oncotarget, 2014 5(20), pp 10048-10057

5. Liu, Tiantian#; Brown, Taylor C#; Juhlin, C Christofer; Andreasson, Adam; Wang, Na; Backdahl, Martin; Healy, James M;  Prasad, Manju L;   Korah, Reju;   Carling, Tobias;   Xu, Dawei; Larsson, Catharina, The activating TERT promoter mutation C228T is recurrent in subsets of adrenal tumors., Endocrine-Related Cancer, 2014 21(3), pp 427-434

6. Tiantian Liu; Xiuming Liang; Magnus Björkholm; Jihui Jia; Dawei Xu, The absence of TERT promoter mutations in primary gastric cancer, Gene, 2014 540(2), pp 266-267

7. Kun Wang#, Tiantian Liu#, Li Liu#, Jikai Liu, Cheng Liu, Chang Wang, Nan Ge, Hongbo Ren, Keqiang Yan, Sanyuan Hu, Magnus Björkholm, Yidong Fan, Dawei Xu, TERT Promoter Mutations in Renal Cell Carcinomas and Upper Tract Urothelial Carcinomas, Oncotarget, 2014 5(7), pp 1829-1836

8. Wang, Kun#; Liu, Tiantian#; Ge, Nan#; Liu, Li; Yuan, Xiaotian; Liu, Jikai; Kong, Feng; Wang, Chang; Ren, Hongbo; Yan, Keqiang; Hu, Sanyuan; Xu, Zhonghua; Bjorkholm, Magnus; Fan, Yidong; Zhao, Shengtian; Liu, Cheng; Xu, Dawei, TERT promoter mutations are associated with distant metastases in upper tract urothelial carcinomas and serve as urinary biomarkers detected by a sensitive castPCR., Oncotarget, 2014 5(23), pp 12428-12439

9. Wang, Kun#; Liu, Tiantian#; Liu, Cheng#; Meng, Yan#; Yuan, Xiaotian; Liu, Li; Ge, Nan; Liu, Jikai; Wang, Chang; Ren, Hongbo; Yan, Keqiang; Hu, Sanyuan; Xu, Zhonghua; Fan, Yidong;  Xu, Dawei, TERT Promoter Mutations and TERT mRNA but Not FGFR3 Mutations Are Urinary Biomarkers in Han Chinese Patients With Urothelial Bladder Cancer. 2015 Oncologist, 20(3), pp 263-269

#第一作者或共同第一作者

2. 非第一作者论文

10. Li, Ping; Liu, Tiantian; Liu, Jiajia;   Zhang, Qing;   Lou, Fenglan;   Kong, Feng;   Cheng, Guanghui;   Bjorkholm, Magnus;   Zheng, Chengyun;   Xu, Dawei, Promoter polymorphism in the serotonin transporter (5-HTT) gene is significantly associated with leukocyte telomere length in Han Chinese., PLos One, 2014 9(4), pp e94442-e94442

11. Liu, Zhifang; Li, Qiao; Li, K; Chen, Long; Li, Wwenjuan; Hou, Mi; Liu, Tiantian; Yang, J; Lindvall, C; Bjorkholm, Magnus; Jia, Jihui; Xu, Dawei, Telomerase reverse transcriptase promotes epithelial-mesenchymal transition and stem cell-like traits in cancer cells., Oncogene, 2013 32(36), pp 4203-4213

12. Li, Wenjuan; Zhao, Li; Zang, Wen; Liu, Zhifang; Chen, Long; Liu, Tiantian; Xu, Dawei;  Jia, Jihui, Histone demethylase JMJD2B is required for tumor cell proliferation and survival and is overexpressed in gastric cancer., Biochem Biophys Res Commun, 2011 416(3-4), pp 372-378