牟坤，主任医师，副教授，硕士研究生导师。2006-2014曾先后3次赴瑞典卡罗琳斯卡医学院癌症中心，参与QM-FISH技术的开发和乳腺癌分子病理的合作研究。2012获英国病理学会颁发的中-欧病理学合作奖。近年来，作为负责人先后承担国家自然科学基金面上项目2项，省部级项目2项，国际合作项目1项。目前担任中国抗癌协会肿瘤病理专业委员会青年委员，中国抗癌协会肿瘤病理专业委员会乳腺肿瘤病理学组委员，中国研究型医院学会超微与分子病理学专业委员会委员，山东省疼痛学会病理学分会副主任委员，山东省医师协会临床病理科医师分会神经病理学组副组长。
Publications
Xue M#, Zhang K#, Mu K#, Xu J, Yang H, Liu Y, Wang B, Wang Z, Li Z, Kong Q, Li X, Wang H, Zhu J, Zhuang T. Regulation of estrogen signaling and breast cancer proliferation by a ubiquitin ligase TRIM56. Oncogenesis. 2019 Apr 18;8(5):30. Hou Y, Li X, Li Q, Xu J, Yang H, Xue M, Niu G, Zhuo S, Mu K, Wu G, Li X, Wang H, Zhu J, Zhuang T. STAT1 facilitates estrogen receptor α transcription and stimulates breast cancer cell proliferation. J Cell Mol Med. 2018 Dec;22(12):6077-6086. Wang K, Li Q, Shi R, Yang D, Zou W, Mu K. Increased CD105 expression is associated with disease progression in phyllodes tumors - A report of a borderline phyllodes tumor with lung metastases and a study of 54 phyllodes tumors. Ann Diagn Pathol. 2018 Feb;32:4-9. Zhuang T, Yu S, Zhang L, Yang H, Li X, Hou Y, Liu Z, Shi Y, Wang W, Yu N, Li A, Li X, Li X, Niu G, Xu J, Hasni MS, Mu K, Wang H, Zhu J. SHARPIN stabilizes estrogen receptor α and promotes breast cancer cell proliferation. Oncotarget. 2017 Aug 19;8(44):77137-77151. Mackay A, Burford A, Carvalho D, Izquierdo E, Fazal-Salom J, Taylor KR, Bjerke L, Clarke M, Vinci M, Nandhabalan M, Temelso S, Popov S, Molinari V, Raman P, Waanders AJ, Han HJ, Gupta S, Marshall L, Zacharoulis S, Vaidya S, Mandeville HC, Bridges LR, Martin AJ, Al-Sarraj S, Chandler C, Ng HK, Li X, Mu K, Trabelsi S, Brahim DH, Kisljakov AN, Konovalov DM, Moore AS, Carcaboso AM, Sunol M, de Torres C, Cruz O, Mora J, Shats LI, Stavale JN, Bidinotto LT, Reis RM, Entz-Werle N, Farrell M, Cryan J, Crimmins D, Caird J, Pears J, Monje M, Debily MA, Castel D, Grill J, Hawkins C, Nikbakht H, Jabado N, Baker SJ, Pfister SM, Jones DTW, Fouladi M, von Bueren AO, Baudis M, Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma. Cancer Cell. 2017 Oct 9;32(4):520-537.e5. Yang H, Yu S, Wang W, Li X, Hou Y, Liu Z, Shi Y, Mu K, Niu G, Xu J, Wang H, Zhu J, Zhuang T. SHARPIN Facilitates p53 Degradation in Breast Cancer Cells. Neoplasia. 2017 Feb;19(2):84-92. Pan A, Zhou Y, Mu K, Liu Y, Sun F, Li P, Li L. Detection of gene copy number alterations in DCIS and invasive breast cancer by QM-FISH. Am J Transl Res. 2016 Nov 15;8(11):4994-5004. Ma X, Guo P, Qiu Y, Mu K, Zhu L, Zhao W, Li T, Han L. Loss of AIM2 expression promotes hepatocarcinoma progression through activation of mTOR-S6K1 pathway. Oncotarget. 2016 Jun 14;7(24):36185-36197. Zhou X, Zhang J, Yun H, Shi R, Wang Y, Wang W, Lagercrantz SB, Mu K. Alterations of biomarker profiles after neoadjuvant chemotherapy in breast cancer: tumor heterogeneity should be taken into consideration. Oncotarget. 2015 Nov 3;6(34):36894-902. Mu K, Li L, Yang Q, Yun H, Kharaziha P, Ye DW, Auer G, Lagercrantz SB, Zetterberg A. A standardized method for quantifying proliferation by Ki-67 and cyclin A immunohistochemistry in breast cancer. Ann Diagn Pathol. 2015 Aug;19(4):243-8. Wei Q, Guo P, Mu K, Zhang Y, Zhao W, Huai W, Qiu Y, Li T, Ma X, Liu Y, Chen X, Han L. Estrogen suppresses hepatocellular carcinoma cells through ERβ-mediated upregulation of the NLRP3 inflammasome. Lab Invest. 2015 Jul;95(7):804-16. Yun H, Shi R, Yang Q, Zhang X, Wang Y, Zhou X, Mu K. Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy. Sci Rep. 2014 Dec 18;4:7548. Wei Q#, Mu K#, Li T, Zhang Y, Yang Z, Jia X, Zhao W, Huai W, Guo P, Han L. Deregulation of the NLRP3 inflammasome in hepatic parenchymal cells during liver cancer progression. Lab Invest. 2014 Jan;94(1):52-62. Zhang Q, Liu LY, Wang F, Mu K, Yu ZG. The changes in female physical and childbearing characteristics in China and potential association with risk of breast cancer. BMC Public Health. 2012 May 21;12:368. Mu K, Li L, Yang Q, Zhang T, Gao P, Meng B, Liu Z, Wang Y, Zhou G. Detection of CHK1 and CCND1 gene copy number changes in breast cancer with dual-colour fluorescence in-situ hybridization. Histopathology. 2011 Mar;58(4):601-7. Li L, Li J, Hao C, Zhang C, Mu K, Wang Y, Zhang T. Immunohistochemical evaluation of solid pseudopapillary tumors of the pancreas: the expression pattern of CD99 is highly unique. Cancer Lett. 2011 Nov 1;310(1):9-14. Yang Q, Liu Y, Liu D, Zhang Y, Mu K. Association of polymorphisms in the programmed cell death 1 (PD-1) and PD-1 ligand genes with ankylosing spondylitis in a Chinese population. Clin Exp Rheumatol. 2011 Jan-Feb;29(1):13-8. Gao P, Zhou GY, Zhang QH, Su ZX, Zhang TG, Xiang L, Wang Y, Zhang SL, Mu K. Lymphangiogenesis in gastric carcinoma correlates with prognosis. J Pathol. 2009 Jun;218(2):192-200. Li L#, Mu K#, Zhou G, Lan L, Auer G, Zetterberg A. Genomic instability and proliferative activity as risk factors for distant metastases in breast cancer. Br J Cancer. 2008 Aug 5;99(3):513-9.
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