吴哓娟，医学博士，副教授，硕士生导师。

邮箱：xiaojuanwu0709@sdu. edu.cn

工作经历

2003.07-2005.09 山东大学医学院病理教研室 助教

2005.09-2015.09 山东大学医学院病理教研室/齐鲁医院病理科 助教/主治医师

1.2015.09-2016.09 山东大学医学院病理教研室/齐鲁医院病理科 副主任医师

2.2016.09-至今 山东大学医学院病理教研室/齐鲁医院病理科 副教授

主持课题

1. mPRα经PI3K/AKT/mTOR信号通路调控乳腺癌化疗敏感性机制的研究（81402181），国家自然科学基金青年基金，已结题。

2. mPRα经PI3K/Akt-NFκB通路调控乳腺癌浸润转移的机制 教育部博士后基金（2015M572047），已结题。

3. mPRα交互式调控c-RAF/MEK/ERK和PI3K/AKT/mTOR信号通路介导乳腺癌化疗耐药的机制(ZR2019MH069)，山东省自然科学基金面上项目，已结题。

4. FAM83B抑制Hippo通路介导三阴性乳腺癌化疗耐药机制的研究(ZR2023MH105)，山东省自然科学基金面上项目，在研。

发表文章

1. Li P, Zhang H, Sun L, Wu X(通讯作者). Toward precision oncology in LUAD: a prognostic model using single-cell sequencing and WGCNA based on a disulfidptosis relative gene signature. Front Immunol. 16:1581915, 2025.

2. Wang J, Li P, Sun L, Zhang J, Yue K, Wang Y, Wu X(通讯作者). FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma. Apoptosis. 29(5-6):743-756, 2024.

3. Jing Zhang , Jiajia Wang, Ke Yue, Panpan Li, Wenping Shen, Xiaowen Qiao , Yan Wang, Xiaojuan Wu(通讯作者). FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-κB pathway. BMC Pulm Med. 23(1):32, 2023

4. Lin Song, Hui Li, Ran-Ran Ma, Sen Liu, Guo-Hao Zhang, Xiang-Yu Guo, Rui-Nan Zhao, Xiao-Juan Wu(并列通讯), Kai Zhang, Peng Gao. E2F1-initiated transcription of PRSS22 promotes breast cancer metastasis by cleaving ANXA1 and activating FPR2/ERK signaling pathway. Cell Death Dis. 13(11):982, 2022.

5. Jing Zhang, Jing Hu, Weiwei Li, Chunyan Zhang, Peng Su , Yan Wang , Wei Sun  , Xiao Wang , Li Li, Xiaojuan Wu(通讯作者). Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer. Front Oncol. 11:608570, 2021.

6. Wu X, Sun L, Wang X, Su P, Li Z, Zhang C, Wang Y, Gao P, Ma R. Breast Cancer Invasion and Metastasis by mPRα Through the PI3K/Akt Signaling Pathway. Pathol Oncol Res. 22(3):471-6, 2016.

7. Xiang S, Liu YM, Chen X, Wang YW, Ma RR, Wu XJ（并列通讯）, Gao P. ZEB1 expression is correlated with tumor metastasis and reduced prognosis of breast carcinoma in Asian patients. cancer Invest. 33(6):225-31,2015.

8. Wu X（并列第一）, Zhang X, Sun L, Zhang H, Li L, Wang X, Li W, Su P, Hu J, Gao P, Zhou G*. Progesterone negatively regulates BCRP in progesterone receptor-positive human breast cancer cells. Cell Physiol Biochem. 32(2):344-54, 2013.

9. Li W, Wu X（并列第一）, Xu X, Wang W, Song S, Liang K, Yang M, Guo L, Zhao Y, Li R. Coenzyme Q10 Suppresses TNF-α-Induced Inflammatory Reaction In Vitro and Attenuates Severity of Dermatitis in Mice. Inflammation. 39(1): 281-289,2016

10. Wu X, Zhang X, Zhang H, Su P, Li W, Li L, Wang Y, Liu W, Gao P, Zhou G*. Progesterone Receptor Down-Regulates BCRP Expression via Binding to the Progesterone Response Element in Breast Cancer. Cancer Sci. 103(5):959-67, 2012.

11. Zhang X, Wu X（并列第一）, Li J, Sun Y, Gao P, Zhang C, Zhang H, Zhou G*. MDR1 (multidrug resistence 1) can regulate GCS (glucosylceramide synthase) in breast cancer cells. J Surg Oncol. 104(5):466-71, 2011.

讲授课程

《病理学》，《人体结构与功能3》，《人体结构与功能1》，《研究生实验病理学》等。